基本信息
性别：男
学历：博士研究生
职称：讲师
邮箱：gbshen@mail.jnmc.edu.cn
教育背景
2011.09–2016.06，南开大学，化学学院，有机化学，博士
2007.09–2011.06，鲁东大学，化学与材料科学学院，化学（师范类），学士
工作经历
2020.04–至今，济宁医学院太阳成集团tyc33455cc，讲师
2017.10–2020.03，辰欣药业股份有限公司，药物研发
2016.07–2017.09，凯莱英医药集团，药物研发
教授课程
主讲《制药工艺学》、《化工仪表及自动化》，教授《制药分离工程》、《制药设备与车间设计》。2024年，主持校级实验教学和教学实验室建设研究项目一项：基于设计思维的制药工艺理念融入《制药分离工程实验》教学研究。2021年，主持校级课程思政项目一项：制药工程专业《制药工艺学》课程融入思政元素的探索。
研究领域及方向
药物合成、氢转移化学、计算化学、物理有机化学。
荣誉、奖励及主要社会兼职
1. 2023年，获济宁医学院第二届教学基本功大赛二等奖。
2. 2023年，获济宁医学院第三届教师教学创新大赛二等奖（3/3）。
3. 2023年起，挂职辰欣药业股份有限公司科技副总。
4. 2023年与2022年，指导优秀学士论文两篇。
5. 2020年，获济宁医学院第十届中青年教师教学竞赛三等奖。
主持科研基金项目
1. 山东省医药卫生科技项目：地平类药物潜在基因毒性的理论研究（在研，2024.01–2025.12）
2. 济宁医学院国家自然（社会）科学基金培育项目：左美托咪定消旋化方法研究及其在原料药生产中的应用（2020.01–2022.12）
发表文章
1. Shen, G.-B.;* Luo, G.-Z.; Qian, B.-C.;* Zhu, X.-Q.* Evaluation of Organic Hydride/Acid Pairs as a Type of Thermodynamic-Potential-Regulated Multisite Proton-Coupled Electron Transfer Reagents. J. Org. Chem., 2024, 89, 6205–6221. (JCR Q1, IF=3.3)
2. Shen, G.-B.; Gao, S.-H.; Jia, Y.-W.; Zhu, X.-Q.;* Qian, B.-C.* Establishing the Thermodynamic Cards of Dipine Models’ Oxidative Metabolism on 21 Potential Elementary Steps. Molecules, 2024, 29, 3706. (JCR Q2, IF=4.2)
3. Qian, B.-C.; Wang, X.; Wang, Q.; Zhu, X.-Q.;* Shen, G.-B.* Thermodynamic evaluations on the acceptorless dehydrogenation and hydrogenation of pre-aromatic and aromatic N-heterocycles in acetonitrile. RSC Adv., 2024, 14(1), 222-232. (JCR Q2, IF=3.9)
4. Zhao, X.; Hou, Y.-L.; Qian, B.-C.;* Shen, G.-B.* Thermodynamic H-Abstraction Abilities of Nitrogen Centered Radical Cations as Potential HAT Catalysts in Y-H Bond Functionalization. ACS Omega, 2024, 9, 26708–26718. (JCR Q2, IF=3.7)
5. Shen, G.-B.;* Qian, B.-C.; Luo, G.-Z.; Fu, Y.-H.;* Zhu, X.-Q.* Thermodynamic Evaluations of Amines as Hydrides or Two Hydrogen Ions Reductants, and Imines as Protons or Two Hydrogen Ions Acceptors, as well as Their Application in Hydrogenation Reactions. ACS Omega, 2023, 8(35), 31984–31997. (JCR Q2, IF=4.1)
6. Fu, Y.-H.*; Wang, F.; Zhao, L.; Zhang, Y.; Shen, G.-B.*; Zhu, X.-Q.* Thermodynamic and Kinetic Studies of the Activities of Aldehydic C-H Bonds toward Their H-Atom Transfer Reactions. ChemistrySelect, 2023, 8, e202204789. (JCR Q3, IF=2.1)
7. Fu, Y.-H.*; Zhang, Y.; Wang, F.; Zhao, L.; Shen, G.-B.; Zhu, X.-Q. Quantitative Evaluation of the Actual Hydrogen Atom Donating Activities of O–H Bonds in Phenols: Structure–Activity Relationship. RSC Adv., 2023, 13, 3295-3305. (JCR Q2, IF=3.9)
8. Fu, Y.-H.*; Jia, T.; Shen, G.-B.; Zhu, X.-Q. Quantitative Evaluation of H-Donating Abilities of C(sp3)–H Bonds of Nitrogen-Containing Heterocycles in Hydrogen Atom Transfer Reaction. RSC Adv., 2023, 13, 16023–16033. (JCR Q2, IF=3.9)
9. Shen, G.-B.;* Qian, B.-C.; Fu, Y.-H.* Zhu, X.-Q.* Thermodynamics of the Elementary Steps of Organic Hydride Chemistry Determined in Acetonitrile and their Applications. Org. Chem. Front., 2022, 9(21), 6001-6062. (JCR Q1, IF=5.5)
10. Shen, G.-B.;* Qian, B.-C.; Zhang, G.-S.; Luo, G.-Z.; Fu, Y.-H.* Zhu, X.-Q.* Thermodynamics Regulated Organic Hydride/Acid Pairs As Novel Organic Hydrogen Reductants. Org. Chem. Front., 2022,9(24), 6833-6848. (JCR Q1, IF=5.5)
11. Shen, G.-B.;* Qian, B.-C.; Fu, Y.-H.* Zhu, X.-Q.* Discovering and Evaluating the Reducing Abilities of Polar Alkanes and Related Family Members as Organic Reductants Using Thermodynamics. J. Org. Chem., 2022, 87(14), 9357-9374. (JCR Q1, IF=3.6)
12. Shen, G.-B.; Yu, H.-Y.; Xu, Z.; Cao, W.; Liu, J.; Xie, L.; Yan, M.* Theoretical Study for Evaluating and Discovering Organic Hydride Compounds as Novel Trifluoromethylation Reagents. Org. Biomol. Chem., 2022, 20(14), 2831-2842. (JCR Q2, IF=3.9)
13. Yan, M.; Qian, B.-C.; Chen, Y.; Luo, G.-Z.; Shen, G.-B.* Theoretical Study for Evaluating and Discovering Organic Hydride Compounds as Potential Novel Methylation Reagents. ACS Omega, 2022, 7(41), 36579-36589. (JCR Q2, IF=4.1)
14. Qian, B.-C.; Zhu, C.-Z.; Shen, G.-B.* The Application of Sulfonyl Hydrazides in Electrosynthesis: A Review of Recent Studies. ACS Omega, 2022, 7, 39531–39561. (JCR Q2, IF=4.1)
15. Qian, B.-C.; Zhang, L.; Zhang, G.-S.; Fu, Y.-H.;* Zhu, X.-Q.;* Shen, G.-B.* Thermodynamic Evaluation on Alkoxyamines of TEMPO Derivatives, Stable Alkoxyamines or Potential Radical Donors? ChemistrySelect, 2022, 7, e202204144. (JCR Q3, IF=2.3)
16. Fu, Y.-H.;* Shen, G.-B.;* Wang, K.; Zhu, X.-Q.* Comparison of Thermodynamic, Kinetic Forces for Three NADH Analogues to Release Hydride Ion or Hydrogen Atom in Acetonitrile. ChemistrySelect, 2021, 6(31), 8007-8010. (JCR Q3, IF=2.1)
17. Shen, G.-B.; Xie, L.; Wang, Y.-X.; Gong, T.-Y.; Wang, B.-Y.; Hu, Y.-H.; Fu, Y.-H.; Yan, M.* Quantitative Estimation of the Hydrogen-Atom-Donating Ability of 4‑Substituted Hantzsch Ester Radical Cations. ACS Omega, 2021, 6(36), 23621-23629. (JCR Q2, IF=3.5)
18. Shen, G.-B.; Xie, L.; Yu, H.-Y.; Liu, J.; Fu, Y.-H.; Yan, M.* Theoretical Investigation on the Nature of 4-Substituted Hantzsch Esters as Alkylation Agents. RSC Adv., 2020, 10(52), 31425-31434. (JCR Q2, IF=3.1)
19. Shen, G.-B.;* Fu, Y.-H.; Zhu, X.-Q.* Thermodynamic Network Cards of Hantzsch Ester, Benzothiazoline, and Dihydrophenanthridine Releasing Two Hydrogen Atoms or Ions on 20 Elementary Steps. J. Org. Chem., 2020, 85(19), 12535-12543. (JCR Q1, IF=4.4)
发表专利
党祥玉，沈广宾. 一种盐酸伊立替康的制备方法. ZL201911425135.1